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Determinantes genéticos e ambientais dos marcadores plaquetários
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ISBN10: 6630064356
ISBN13: 9786630064353
Publisher: Edicoes Nosso Conhecimento
Published: Jul 7 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786630064353
Publisher: Edicoes Nosso Conhecimento
Published: Jul 7 2026
Pages: 64
Weight: 0.22
Height: 0.15 Width: 6.00 Depth: 9.00
Language: Portuguese
O tamanho e a contagem das plaquetas estão associados à isquemia cardÃaca e ao acidente vascular cerebral isquémico, duas das formas mais comuns de doença cardiovascular aguda. Embora a contagem de plaquetas (PC) seja uma medida clÃnica comum, a avaliação do tamanho das plaquetas através do volume plaquetário médio (MPV) - o tamanho médio das plaquetas numa amostra de sangue - e da amplitude de distribuição plaquetária (PDW) - a variância da curva do volume plaquetário - é menos frequente. O objetivo geral da minha investigação é caracterizar estas três medidas quantitativas das plaquetas numa população de indivÃduos saudáveis e avaliar os determinantes genéticos e ambientais destas caracterÃsticas. Foram examinados preditores clÃnicos e antropométricos, para além de um estudo de associação do genoma completo (GWAS) realizado para cada uma destas três caracterÃsticas quantitativas das plaquetas. Foram identificados 23 SNPs associados a um nÃvel de significância sugestivo (p
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