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Compreender a base molecular da migração das células germinativas primordiais
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ISBN10: 6207734904
ISBN13: 9786207734900
Publisher: Edicoes Nosso Conhecimento
Published: Jun 29 2024
Pages: 52
Weight: 0.20
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786207734900
Publisher: Edicoes Nosso Conhecimento
Published: Jun 29 2024
Pages: 52
Weight: 0.20
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Portuguese
O peixe-rei de cauda amarela (ordem Perciformes) habita as águas tropicais e temperadas do hemisfério sul. Podem ser cultivados com sucesso na Austrália e, por conseguinte, muitos pormenores fundamentais sobre a base molecular do desenvolvimento larvar podem ser facilmente estudados. Em particular, o mecanismo molecular preciso da formação das gónadas é de interesse devido às implicações na nossa compreensão do desenvolvimento dos gâmetas. Até à data, pouco se sabe sobre o mecanismo de migração das células germinativas primordiais (PGC) que conduz à formação das gónadas em qualquer peixe perciforme. Neste estudo, isolámos três genes-chave do peixe-rei de cauda amarela que podem estar envolvidos na migração das PGC, nomeadamente o fator derivado de células estromais (SDF1), o recetor de quimiocinas 4 (CXCR4) e o recetor de quimiocinas 7 (CXCR7). As análises da expressão genética mostram que são produzidos continuamente ao longo de 1-22 dias após a eclosão e cada um deles apresenta uma localização distinta nas fases larvares investigadas. Em conjunto, estes resultados fornecem uma plataforma para estudos futuros sobre a maquinaria molecular dos peixes perciformes migradores PGC, com vista ao desenvolvimento final de reprodutores substitutos inovadores para o atum rabilho do Sul.
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