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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Pna: Potentially better alternative for on-surface DNA detection

Pna: Potentially better alternative for on-surface DNA detection

Ghosh Srabani

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ISBN10: 3659693901
ISBN13: 9783659693908
Publisher: Lap Lambert Academic Pub
Published: Apr 9 2015
Pages: 232
Weight: 0.76
Height: 0.53 Width: 6.00 Depth: 9.00
Language: English
Peptide Nucleic Acid (PNA) is an alternative nucleic acid, capable of sequence-specific binding with complementary DNA with higher affinity compared to DNA, which is reflected in the higher melting temperature value for PNA-DNA duplexes compared to that for DNA-DNA duplexes. It is this property of PNA that makes this molecule a potentially better alternative than DNA in nucleic acid detection technologies. Though the DNA SAMs have been applied in the micro scale as well as nanoscale nucleic acid sensing experiments, the problems of lack of sensitivity and reproducibility persist, probably because of defects in the generally disordered DNA films. In the present study, the effectiveness of ssPNA strands as sensor probes for on-surface DNA detection has been tested.

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