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Modern Adaptive Randomized Clinical Trials: Statistical and Practical Aspects
Hardcover
Series: Chapman & Hall/CRC Biostatistics, Book 81
Medical ReferenceProbability & Statistics
ISBN13: 9781482239881
Publisher: Crc Pr Inc
Published: Jun 30 2015
Pages: 536
Weight: 2.30
Height: 1.10 Width: 6.20 Depth: 9.20
Language: English
This book aids in identifying when to apply adaptive randomization designs in practice. Featuring contributions from statisticians, clinical trialists, and subject-matter experts in academia and industry, the text discusses restricted, covariate-adaptive, response-adaptive, and covariate-adjusted response-adaptive randomization designs, as well as randomized designs with treatment selection. It describes a successful implementation of a single pivotal phase II/III adaptive trial in infants with proliferating hemangioma, addresses practical aspects of phase II dose-ranging studies, and examines statistical monitoring and interim analysis issues in response-adaptive randomized clinical trials.
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