Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Molecular Study of Correlation Between Insulin Resistance and PCOS

Molecular Study of Correlation Between Insulin Resistance and PCOS

Atheab Mohammad Ibraheem Mezaal
Nader Mohammed Ibrahem
Aziz Ismail Hussein

Paperback

Genetics

ISBN10: 3659424404
ISBN13: 9783659424403
Publisher: Lap Lambert Academic Pub
Published: Mar 5 2015
Pages: 124
Weight: 0.42
Height: 0.29 Width: 6.00 Depth: 9.00
Language: English
Polycystic ovary syndrome (PCOS) is one of the most common female endocrine disorders, but there is strong evidence that it can to a large degree be classified as a genetic disease.It is thought to be one of the leading causes of female subfertility and the most frequent endocrine problem in women of reproductive age.Women with PCOS are more insulin resistant, and up to 40% of these patients have impaired glucose tolerance. They are at an increased (3-7 times) risk of developing early-onset type 2 diabetes, the risk being greater in obese PCOS patients and those with a family history of type 2 diabetes.Insulin plays both direct and indirect roles in the pathogenesis of androgen excess in PCOS.A highly polymorphic stretch of DNA lying 360 bp upstream of the initiation of transcription of the INS gene called Variable Number of Tandem Repeats (VNTR). There are three classes of (VNTR) in the insulin gene (class I, class II and class III) .Any mutations in this region may be effect on insulin gene (INS) expressions .

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