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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
In-Silico Approach For Designing Thiazolidinone Based Analogues For Anti-Inflammatory Activity

In-Silico Approach For Designing Thiazolidinone Based Analogues For Anti-Inflammatory Activity

Rana, Aniruddhasinh

Paperback

Chemistry

Publisher Price: $45.50

ISBN10: 9999322735
ISBN13: 9789999322737
Publisher: Eliva Press
Published: Sep 11 2024
Pages: 90
Weight: 0.29
Height: 0.19 Width: 6.00 Depth: 9.00
Language: English
This book mainly covers In-silico studies of thiazolidinone based analogues in order to identify prominent binding pockets for inhibiting Cyclooxygenase (COX), Lipoxygenase (LOX), and Tumor Necrosis Factor (TNF-α) for anti-inflammatory activity. Random synthesis and random screening of these compounds for various biological activities is very tedious, costly and less productive work. Modern chemistry demands molecular modelling, and pre-synthesis biological activity predictions through docking and other techniques for effective, speedy and target based research. Focusing on this, in this book interactions between thiazolidinone based analogues with these enzyme binding pockets, prediction of binding affinity, fragments responsible for the interaction with enzyme binding site, and their mode of interactions with the active sites have been highlighted. This book provides the prominent way to design new anti-inflammatory agents based on thiazolidinone moieties with better inhibition potency.

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