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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Iron as Environmental Factor in the Pathogenesis of Crohn's Disease-Like Ileitis

Iron as Environmental Factor in the Pathogenesis of Crohn's Disease-Like Ileitis

Werner, Tanja

Paperback

PhilosophyMedical Reference

Currently unavailable to order

ISBN10: 3832527699
ISBN13: 9783832527693
Publisher: Logos Verlag Berlin
Published: Feb 20 2011
Pages: 121
Weight: 0.40
Height: 0.21 Width: 5.71 Depth: 7.91
Language: English
Inflammatory bowel diseases (IBD) including ulcerative colitis and Crohn's disease
(CD) are chronic disorders of the gastrointestinal tract. Iron replacement therapy
is a common treatment in anemic CD patients, but oral iron supplements seem to be
less tolerated. Pathogenesis of CD has been attributed to intestinal bacteria and
environmental factors including dietary components like iron that trigger disease in
a genetically predisposed host. The aim of this study was to characterize the
interrelationship between iron, the gut microbiota and the development of chronic
ileitis in a murine model of CD.

Experimental results indicate that luminal iron sulfate deprivation in combination
with systemic iron repletion inhibits the development of inflammation in TNF { Delta
ARE/WTmice. The mechanisms imply changes in the gut microbiota as well as inhibition
of endoplasmic reticulum stress and apoptosis in the intestinal epithelium.

In conclusion, luminal iron may directly affect intestinal epithelial function or
generate a pathological milieu in the intestine that triggers epithelial cell
stress-associated apoptosis through changes in the microbial homeostasis. These data
may offer a new possibility for the treatment of chronic intestinal inflammation and
anemia in CD patients through modulation of the patients' iron status. In addition,
oral replacement therapy with iron sulfate may trigger inflammatory processes
associated with progression of CD-like ileitis and intravenous therapy should be
preferred.

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