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Geni e cancro orale
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ISBN10: 6208614899
ISBN13: 9786208614898
Publisher: Edizioni Sapienza
Published: Jan 30 2025
Pages: 152
Weight: 0.47
Height: 0.35 Width: 6.00 Depth: 9.00
Language: Italian
ISBN13: 9786208614898
Publisher: Edizioni Sapienza
Published: Jan 30 2025
Pages: 152
Weight: 0.47
Height: 0.35 Width: 6.00 Depth: 9.00
Language: Italian
In questo libro studiamo i geni coinvolti nella carcinogenesi orale e il loro utilizzo nella terapia genica. La cancerogenesi è un processo complesso a più fasi in cui gli eventi genetici all'interno delle vie di trasduzione del segnale che governano la normale fisiologia cellulare vengono alterati quantitativamente. La base genetica del cancro è ormai ben consolidata. In condizioni normali, queste vie eccitatorie e inibitorie strettamente controllate regolano la biologia dei cheratinociti orali. Le funzioni cellulari di base sotto questi controlli includono la divisione cellulare, la differenziazione, la senescenza e l'adesione. È stato identificato che fattori genetici come oncogeni, geni oncosoppressori e geni regolatori sono coinvolti nella carcinogenesi orale con questi fattori di rischio dipendenti e indipendenti. MiRNA e Ras L'oncogene è uno dei geni geneticamente deregolamentati più frequentemente nel cancro orale. La terapia genica per il cancro rappresenta la maggior parte degli studi clinici sulla terapia genica. Gli obiettivi a questo scopo includono la sostituzione di geni oncosoppressori, geni suicidi per attivare profarmaci, trasferimento genico basato su kine di geni antiangiogenici.
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