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Sélénium, gènes codant pour les sélénoprotéines et cancers dépendants de CHEK2
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ISBN10: 6209665616
ISBN13: 9786209665615
Publisher: Editions Notre Savoir
Published: Feb 27 2026
Pages: 128
Weight: 0.40
Height: 0.30 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786209665615
Publisher: Editions Notre Savoir
Published: Feb 27 2026
Pages: 128
Weight: 0.40
Height: 0.30 Width: 6.00 Depth: 9.00
Language: French
Dans notre étude, nous avons cherché à déterminer si la concentration en sélénium pouvait être utilisée comme marqueur utile pour la détection précoce des cancers chez un groupe d'individus présentant des mutations CHEK2 et chez des patients non sélectionnés. Nous avons constaté une association très significative entre une concentration élevée en sélénium et une probabilité plus faible de détection du cancer dans les groupes testés. Cette observation est particulièrement utile pour les personnes porteuses de la mutation CHEK2, qui présentent un risque accru de cancer. Nous avons également trouvé des preuves d'une association entre rs1139793 dans TXNDR2 et rs5845 dans SEP15 et le risque de cancer chez les porteurs de CHEK2, ce qui pourrait être utile pour déterminer l'évaluation du risque personnel. En résumé, la concentration sérique en sélénium semble être un marqueur utile pour la sélection des personnes devant subir des examens de surveillance tels que la tomodensitométrie ou la coloscopie afin de détecter les stades les plus précoces des cancers bronchiques et colorectaux. Elle devrait également être prise en compte dans le programme de surveillance des personnes chez lesquelles une mutation CHEK2 a été détectée. Des analyses supplémentaires sont nécessaires pour élucider le rôle des variations des gènes sélénoprotéiques sur le risque de cancer chez les porteurs de CHEK2.
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