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Papillomavirus bovin: ce que nous savons et ce que nous devrions savoir
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ISBN10: 6202203218
ISBN13: 9786202203210
Publisher: Editions Notre Savoir
Published: Sep 13 2025
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: French
ISBN13: 9786202203210
Publisher: Editions Notre Savoir
Published: Sep 13 2025
Pages: 120
Weight: 0.38
Height: 0.28 Width: 6.00 Depth: 9.00
Language: French
Le papillomavirus bovin (BPV) est l'agent étiologique de la papillomatose bovine, une maladie infectieuse qui cause des pertes économiques importantes au bétail, caractérisée par la présence de papillomes qui régressent spontanément. Cependant, ils peuvent persister et évoluer vers une tumeur maligne. Cette étude a identifié la présence du BPV-2 dans plus de 80 % des échantillons. L'analyse histopathologique a révélé des altérations importantes, notamment la présence de fibroblastes transformés, renforçant le rôle du virus dans la malignité. Ce résultat suggère également une voie d'infection par le sang. L'IHC a révélé la présence de la protéine L1 dans l'épiderme et le derme, suggérant une infection productive à d'autres endroits. Un marquage expressif de l'oncoprotéine E7 dans toutes les couches de l'épithélium et du stroma a été observé, démontrant l'activité virale dans les fibroblastes. La CA a révélé que tous les genres de BPV ont une action clastogène similaire. Les résultats confirment le rôle oncogène du BPV dans la création d'un microenvironnement favorable à la transformation maligne. Les particules de BPV ont été isolées avec succès à partir d'échantillons dans lesquels le BPV-2 a été identifié, à l'aide d'une nouvelle technique d'isolement du papillomavirus.
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