Composés mono-, di-, tri- et tétra-spiro-hétérocycliques: avancées récentes

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ISBN10: 3841682111
ISBN13: 9783841682116
Publisher: Editions Notre Savoir
Published: Apr 15 2025
Pages: 56
Weight: 0.19
Height: 0.13 Width: 6.00 Depth: 9.00
Language: French

Les isatines et leurs dérivés fonctionnalisés en C-3 occupent une place de choix dans la synthèse organique et la chimie médicinale. Les isatines N-substituées et les isatines portant différents substituants sur un cycle phényle ont été utilisées dans des réactions à deux, trois ou quatre composants conduisant à la formation de structures spiro-hétérocycliques à cinq et six chaînons portant un groupement 2-oxindole. Le développement de méthodologies diastéréo- et énantiosélectives contenant deux à quatre stéréocentres pour la synthèse de structures cycliques spiro-condensées est un domaine d'intérêt actuel. Dans cette revue, nous avons présenté plusieurs synthèses récentes de spirohétérocycles à base d'isatine dans différents milieux, ce qui témoigne d'un intérêt significatif dans ce domaine et laisse présager des réactions chimiques encore plus intéressantes. Dans les réactions mentionnées, certaines nécessitent de la chaleur pour être accélérées et d'autres sont assistées par micro-ondes. Dans certains cas, une évaluation biologique a également été mentionnée. Nous espérons que cette revue suscitera un vif intérêt chez les chercheurs ou les chimistes organiques pour la synthèse organique à base d'isatine de composés biologiquement actifs.

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