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Drug Monitoring and Clinical Chemistry: Volume 5

Drug Monitoring and Clinical Chemistry: Volume 5

Hardcover

Series: Handbook of Analytical Separations, Book 5

Medical ReferenceChemistry

ISBN10: 0444509720
ISBN13: 9780444509727
Publisher: Elsevier Science
Published: May 15 2004
Pages: 378
Weight: 1.56
Height: 0.88 Width: 6.14 Depth: 9.21
Language: English

Drug Monitoring and Clinical Chemistry, the 5th volume in the Handbook of Analytical Separations series, gives an overview about methods to analyse drugs in biological fluids. The most widely used methods to analyse drugs in biological fluids. i.e. chromatographic methods, CE and immunoassays are described in detail. For important drugs, an overview about the methods available and a comparison of the techniques should be given to enable the reader to choose the right method depending on laboratory equipment, staff, the aim of the investigation etc. Other general aspects important for conducting therapeutic drug monitoring or pharmacokinetics studies are also covered, i.e. sample preparation, validation of the analytical methods and pharmacokinetic methods for interpreting the data. Areas where therapeutic drug monitoring is used frequently such as antibiotics, immunosuppressant drugs, antipsychotic and anticancer drugs will be discussed in detail. In addition, the important field of phenotyping and genotyping for therapy optimisation with special focus on real-life applications is also covered.

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