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Controlled Epidemiological Studies

Controlled Epidemiological Studies

Hardcover

Series: Chapman & Hall/CRC Biostatistics

Medical ReferenceProbability & Statistics

ISBN10: 0367186780
ISBN13: 9780367186784
Publisher: Crc Pr Inc
Published: May 26 2023
Pages: 440
Weight: 1.84
Height: 1.00 Width: 6.14 Depth: 9.21
Language: English

This book covers classic epidemiological designs that use a reference/control group, including case-control, case-cohort, nested case-control and variations of these designs, such as stratified and two-stage designs. It presents a unified view of these sampling designs as representations of an underlying cohort or target population of interest. This enables various extended designs to be introduced and analysed with a similar approach: extreme sampling on the outcome (extreme case-control design) or on the exposure (exposure-enriched, exposure-density, countermatched), designs that re-use prior controls and augmentation sampling designs. Further extensions exploit aggregate data for efficient cluster sampling, accommodate time-varying exposures and combine matched and unmatched controls. Self-controlled designs, including case-crossover, self-controlled case series and exposure-crossover, are also presented. The test-negative design for vaccine studies and the use of negative controls for bias assessment are introduced and discussed.

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Probability & Statistics