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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Cytogenetics

Cytogenetics

Mallikarjunaiah, Shanthala
Karunyaa R., Jyoti

Paperback

Genetics

ISBN10: 6208470234
ISBN13: 9786208470234
Publisher: LAP Lambert Academic Publishing
Published: Oct 9 2025
Pages: 80
Weight: 0.26
Height: 0.19 Width: 6.00 Depth: 9.00
Language: English
Acute myeloid leukemia (AML) is a category of diseases with a common aggressive clinical presentation but with a poor prognosis and management that is dependent upon the underlying genetic characteristics of the neoplasm. Genetic analysis of AML is essential, and conventional karyotyping is the key factor in diagnosis and management of AML. In this study, 65952 cases were studied from the data, 251 males (63.87%) and 142 females (36.13%). The range of age in this study was 2 months to 87 years. The maximum chromosomal abnormality was observed in males compared to females, median age of 31 years. Individual karyotypes showed that total 23 types of rare cytogenetic abnormalities were recorded. The analysis of AML data showed that incidence of ph+ve chromosome, complex karyotypes, tetraploid/near tetraploid (T/NT), t(1;2)(p35;p22), t(1;3)(p36.2;p26.2) t(10;12)(p15.2;q24.11), high hyperploidy, >=49 chromosomes; tetraploidy (4n = 92 chromosomes) are marker karyotype, which were of significance. del Y or X, 9,7; Abn19q13; Trisomy22, Core binding factor (CBF) (+ve AML). The highest % incidence of individual rare abnormalities in AML patients is t(1;2)(p35;p22), t(1;3)(p36.2;p26.2) t(10;12).

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