Xiaodong Wang

High Quality Content by WIKIPEDIA articles! Xiaodong Wang (simplified Chinese: 王晓东; traditional Chinese: 王曉東; pinyin: Wāng Xiǎodōng, born 1963) is an American biochemist best known for his work with cytochrome c. His laboratory developed an in-vitro assay for the activation of the apoptosis related proteinase Caspase-3. This allowed the biochemical purification a complex of Cytochrome c, Caspase-9 and the Apoptotic Protease Activating factor-1 (Apaf-1). These components are essential for forming a ternary complex called the apoptosome that activates Caspase-3 downstream of the intracellular or mitochondrial pathway of apoptosis.