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Target Identification and Validation in Drug Discovery: Methods and Protocols
Paperback
Series: Methods in Molecular Biology, Book 986
ISBN13: 9781493962785
Publisher: Humana Pr
Published: Aug 19 2016
Pages: 371
Weight: 1.48
Height: 0.80 Width: 7.00 Depth: 10.00
Language: English
Part I- Background
1. The Path to Oncology Drug Target Validation - an Industry Perspective
Marta Cortés-Cros, Tobias Schmelzle, Volker M. Stucke and Francesco Hofmann
Part II- DNA as a tool to Modulate Drug Targets
2. Identification of Aptamers as Specific Binders and Modulators of Cell-Surface Receptor Activity
Henning Ulrich and Carsten Wrenger
3. The Design and Structure-functional Properties of DNA-based Immunomodulatory Sequences
Nikolai V. Kuznetsov
Part III-RNA Interference: From Design to Data Analysis
4. siRNA Design Principles and Off-target Effects
Sebastian Petri and Gunter Meister
5. Western Blot Evaluation of siRNA Delivery by pH Responsive Peptides
Wanling Liang, A. James Mason and Jenny K.W. Lam
6. High Throughput RNAi Screening for the Identification of Novel Targets
Meredith C. Henderson and David O. Azorsa
7. Integration of RNAi and Small Molecule Screens to Identify Targets for Drug Development
Konstantinos Drosopoulos and Spiros Linardopoulos
8. CellProfiler and KNIME: Open Source Tools for High Content Screening
Martin Stöter, Antje Niederlein, Rico Barsacchi, Felix Meyenhofer, Holger Brandl and Marc Bickle
9. PARP Inhibition as a Prototype for Synthetic Lethal Screens
Xuesong Liu
Part IV-Protein Focused Technologies
10. Structure-Based Target Druggability Assessment
Jean-Yves Trosset and Nicolas Vodovar
11. Validating Pharmacological Disruption of Protein-protein Interactions by Acceptor Photobleaching FRET Imaging
Janos Roszik, Gábor Tóth, János Szöllősi and György Vereb
12. Systematic Analysis of Complex Signal Transduction Pathways using Protein Fragment Complementation Assays
Thomas I. Koblizek, Ann Siehoff and Anthony Pitt
13. Reverse-Phase Protein Microarrays and Their Utility in Drug Development
Maria Isabella Sereni, Mariaelena Pierobon, Roberto Angioli Emanuel F. Petricoin III, and Mitchell J. Frederick
Part V. Innovative Cell Culture Techniques to Mimic Tissue Microenvironments
14. A Cell Culture System that Mimics Chronic Lymphocytic Leukemia Cells Microenvironment for Drug Screening and Characterization
Alessandro Natoni
15. 2-Dimensional vs. 3-Dimensional in vitro Tumor Migration and Invasion Assays
Miriam Zimmermann, Carol Box and Suzanne A. Eccles
16. Tumor Spheroid-based Migration Assays for Evaluation of Therapeutic Agents
Maria Vinci, Carol Box, Miriam Zimmermann and Suzanne A. Eccles
17. The NeuroSphere Assay (NSA) Applied to Neural Stem Cells (NSCs) and Cancer Stem Cells (CSCs)
Rossella Galli
Part VI- Genetically Engineered Animal Models to study Gene Functions
18. Genetically Engineered Animal Models for in vivo Target Identification and Validation in Oncology
Gemma Texidó
19. Target Validation in Mice by Constitutive and Conditional RNAi
Aljoscha Kleinhammer, Wolfgang Wurst, Ralf Kühn
20. In vivo Target Validation by Inducible RNAi in Human Xenograft Mouse Models
Marco Mazzoletti and Gemma Texido
Part VII- Translational Methods to validate Biomarkers
21. Brightfield In Situ Hybridization Methods to Discover Gene Amplific
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