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Trp Channels in Drug Discovery: Volume I
Hardcover
Series: Methods in Pharmacology and Toxicology, Book 0
ISBN13: 9781627030762
Publisher: Springer Nature
Published: Sep 20 2012
Pages: 446
Weight: 2.20
Height: 1.20 Width: 7.10 Depth: 10.00
Language: English
Part I: Introduction
1. Introduction to TRPs: A Quest for Novel Drug Targets
Bernd Nilius
2. TRP-Mediated Cytoskeletal Reorganization: Implications for Disease and Drug Development
Chandan Goswami
Part II: TRP Channels, from A1 to V4
3. TRPA1 in Drug Discovery
Jun Chen, Steve McGaraughty, and Philip R. Kym
4. Canonical Transient Receptor Potential Channel (TRPC) Expression, Regulation, and Function in Vascular and Airway Diseases
Brij B. Singh, Christina M. Pabelick, and Y.S. Prakash
5. TRPM2 Function and Potential as a Drug Target
Barbara A. Miller
6. The Ca2+-Activated Monovalent Cation Selective Channels TRPM4 and TRPM5
Colsoul Barbara, Kecskes Miklos, Philippaert Koenraad, Menigoz Aurelie, and Vennekens Rudi
7. The Emerging Role of TRPM7 in the Regulation of Magnesium Homeostasis
Vladimir Chubanov, Jonathan T. Eggenschwiler, Thomas Gudermann, and Alexey G. Ryazanov
8. TRPM8 Channels as Potential Therapeutic Targets for Pain, Analgesia, and Thermoregulation
David D. McKemy
9. TRPML Channels in Function, Disease, and Prospective Therapies
David A. Zeevi
10. The TRPP Signalling Module: TRPP2/Polycystin 1 and TRPP2/PKD1L1
Alexis Hofherr
11. TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities
Olivier Radresa, Stephen Zicha, William Brown, and Jennifer M.A. Laird
12. Nociceptive and Non-Nociceptive Roles of TRPV3 and Its Druggability
Sungjae Yoo and Sun Wook Hwang
13. TRPV4 and Drug Discovery
Fabien Vincent and Matthew A.J. Duncton
Part III: TRPs and Airways
14. TRP Expression and Function in the Lung Airways
Alexander Dietrich and Thomas Gudermann
15. Hypoxia-Dependent TRP Channel Function in Pulmonary Arterial Smooth Muscle Cells
Beate Fuchs, Hermann Kalwa, Norbert Weissmann, Thomas Gudermann, and Alexander Dietrich
16. Endotoxin-Induced Airway Inflammation and Asthma Models
Zsuzsanna Helyes and Zsófia Hajna
17. Enhanced Cough, Animal Models
Raffaele Gatti, Pamela Pedretti, Romina Nassini, and Marcello Trevisani
18. Capsaicin Inhalation Test in Man
Eva Millqvist
Part IV: TRPs and the Genitourinary (GU) Tract
19. TRP Channels in the Genitourinary (GU) Tract
Ana Charrua and Francisco Cruz
20. Animal Models of Cystitis
Célia D. Cruz and António Avelino
21. Overactive Bladder Models
Roberto Soler, Lysanne Campeau, Claudius Füllhase, and Karl-Erik Andersson
Alexis Hofherr
11. TRPV1 as a Polymodal Sensor: Potential to Discover TRPV1 Antagonists Selective for Specific Activating Modalities
Olivier Radresa, Stephen Zicha, William Brown, and Jennifer M.A. Laird
12. Nociceptive and Non-Nociceptive Roles of TRPV3 and Its Druggability
Sungjae Yoo and Sun Wook Hwang
13. TRPV4 and Drug Discovery
Fabien Vincent and Matthew A.J. Duncton
Part III: TRPs and Airways
14.
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