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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Total Synthesis of Natural Products with Antimicrobial Activity

Total Synthesis of Natural Products with Antimicrobial Activity

Giltrap, Andrew

Paperback

Series: Springer Theses

Medical ReferenceChemistry

ISBN10: 9811342458
ISBN13: 9789811342455
Publisher: Springer Nature
Published: Feb 14 2019
Pages: 268
Weight: 0.91
Height: 0.62 Width: 6.14 Depth: 9.21
Language: English
This thesis focuses on the development of efficient and scalable total syntheses of natural products that can be used as preferred scaffolds for anti-infective drug discovery. It describes the total synthesis of two classes of antimicrobial non-ribosomal peptides (NRPs) - teixobactin and the skyllamycins - with subsequent biological evaluation. The first part describes the first total synthesis of teixobactin by means of a solid-phase peptide synthesis-macrolactamisation approach, yielding a synthetic natural product that can combat a number of clinically relevant Gram-positive bacterial pathogens. The second part describes the first total synthesis of skyllamycins A-C, a family of structurally complex cyclic NRPs, which inhibit the growth of the Pseudomonas aeruginosa biofilms that are responsible for significant mortality among cystic fibrosis patients.

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