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Structure and Function of Gpcrs

Structure and Function of Gpcrs

Hardcover

Series: Topics in Medicinal Chemistry, Book 30

Medical ReferenceChemistryGeneral Science

ISBN10: 3030245896
ISBN13: 9783030245894
Publisher: Springer Nature
Published: Aug 24 2019
Pages: 289
Weight: 1.33
Height: 0.69 Width: 6.14 Depth: 9.21
Language: English
This book introduces readers to the latest advances in G protein-coupled receptor (GPCR) biology. It reviews our current understanding of the structural basis of ligand binding and allosteric mechanisms, following a decade of technological breakthroughs. Several examples of structure-based drug discovery are presented, together with the future challenges involved in designing better drugs that target GPCRs. In turn, the book illustrates the important concept of GPCR biased signaling in physiological contexts, and presents fluorescent- and light-based methodologies frequently used to measure GPCR signaling or to trace their dynamics in cells upon ligand activation.

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