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Structure-Based Drug Discovery
Paperback
Series: Methods in Molecular Biology, Book 841
ISBN13: 9781493961375
Publisher: Humana Pr
Published: Aug 23 2016
Pages: 385
Weight: 1.51
Height: 0.81 Width: 7.00 Depth: 10.00
Language: English
1. The Utility of Structural Biology in Drug Discovery
Leslie W. Tari
2. Genetic Construct Design and Recombinant Protein Expression for Structural Biology
Suzanne C. Edavettal, Michael J. Hunter, and Ronald V. Swanson
3. Purification of Proteins for Crystallographic Applications
Daniel C. Bensen
4. Protein Crystallization for Structure-Based Drug Design
Isaac D. Hoffman
5. X-Ray Sources and High-Throughput Data Collection Methods
Gyorgy Snell
6. The Use of Molecular Graphics in Structure-Based Drug Design
Paul Emsley and Judit É. Debreczeni
7. Crystallographic Fragment Screening
John Badger
8. The Role of Enzymology in a Structure-Based Drug Discovery Program: Bacterial DNA Gyrase
Mark L. Cunningham
9. Leveraging Structural Information for the Discovery of New Drugs: Computational Methods
Toan B. Nguyen, Sergio E. Wong, and Felice C. Lightstone
10. Chemical Informatics - Using Molecular Shape Descriptors in Structure-Based Drug Design
Andy Jennings
11. Accounting for Solvent in Structure-Based Drug Design
Leslie W. Tari
12. Structure-Based Drug Design on Membrane Protein Targets: Human Integral Membrane Protein 5-Lipoxygenase-Activating Protein
Andrew D. Ferguson
13. Application of SBDD to the Discovery of New Antibacterial Drugs
John Finn
14. Leveraging SBDD in Protein Therapeutic Development: Antibody Engineering
Gary L. Gilliland, Jinquan Luo, Omid Vafa, and Juan Carlos Almagro
15. A Medicinal Chemistry Perspective on Structure-Based Drug Design and Development
Shawn P. Maddaford
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