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Structural and Functional Characterization of the Immunoproteasome

Structural and Functional Characterization of the Immunoproteasome

Paperback

Series: Springer Theses

Chemistry

ISBN10: 3319378104
ISBN13: 9783319378107
Publisher: Springer Nature
Published: Aug 23 2016
Pages: 82
Weight: 0.35
Height: 0.22 Width: 6.14 Depth: 9.21
Language: English
In this acclaimed thesis, Eva Maria Huber reveals ground-breaking results by elucidating the crystal structure of the murine immunoproteasome in complex with a selective inhibitor. Huber does this by performing multidisciplinary methodologies including X-ray crystallography, fluorescence spectroscopy and mutagenesis experiments. Her exceptional results explore the immunoproteasome complex structures and are of outstanding importance for future scientific research especially in the pharmaceutical industry. These results will enable the functional analysis of individual proteasome subunits and support the development of novel drugs for autoimmune diseases such as multiple sclerosis or rheumatoid arthritis.

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