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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases

Sequence-Specific DNA Binders for the Therapy of Mitochondrial Diseases

Hidaka, Takuya

Hardcover

Series: Springer Theses

Technology & EngineeringChemistryGenetics

ISBN10: 9811684359
ISBN13: 9789811684357
Publisher: Springer Nature
Published: Jan 4 2022
Pages: 94
Weight: 0.74
Height: 0.31 Width: 6.14 Depth: 9.21
Language: English
This book describes the author's work on the development of sequence-specific DNA binders for the therapy of mitochondrial diseases. In the first chapter, the author provides a detailed background of pyrrole-imidazole polyamides (PIPs) and mitochondrial disease research followed by chapters presenting the author's own research and discoveries. Firstly, the developed compounds called MITO-PIPs, which recognize specific sequences in mitochondrial DNA, are presented. The following chapter demonstrates how, by introducing a DNA alkylating reagent into a MITO-PIP that recognizes the adjacent sequence to a target mutation, the copy number of mutated mitochondrial DNA was successfully reduced in live cells. Furthermore, because nuclear DNA is another important target for treating mitochondrial diseases, the author demonstrated that tri-arginine vectors can enhance nuclear uptake of PIPs and improve their biological activity in cells.

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