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Regulation of Cancer Immune Checkpoints: Molecular and Cellular Mechanisms and Therapy

Regulation of Cancer Immune Checkpoints: Molecular and Cellular Mechanisms and Therapy

Hardcover

Series: Advances in Experimental Medicine and Biology, Book 1248

Medical ReferenceBiology

ISBN10: 9811532656
ISBN13: 9789811532658
Publisher: Springer Nature
Published: Mar 18 2020
Pages: 653
Weight: 2.42
Height: 1.44 Width: 6.14 Depth: 9.21
Language: English
Introduction.- Molecular and cellular functions of CTLA-4 pathway.- Roles of PD-1/PD-L1 pathway: signaling, cancer, and beyond.- Discovery of new immune checkpoints: family grows up.- Mechanisms of resistance to checkpoint blockade therapy.- Molecular events behind adverse effects.- Rational discovery of response biomarkers.- Spatiotemporal changes in checkpoint molecule expression.- Functions of checkpoint molecules beyond immune evasion.- Genetic alterations and checkpoint expression.- Regulations on messenger RNA: wires and nodes.- Folded or degraded in endoplasmic reticulum.- Mono- and poly-ubiquitination: tags for fates.- Lysosome as the black hole for checkpoint molecules.- Phosphorylation: a fast switch for checkpoint signalling.- Palmitoylation as a signal for delivery.- Checkpoints under traffic control: from and to organelles.- Exosome and secretion: action on?.- Macromolecules and antibody-based drugs.- Mechanisms inspired targeting peptides.- Small molecular inhibitors.- Therapeutic development of immune checkpoint blockers.- Concluding remarks

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