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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Reconstituted Sodium Pump: A Historical Account

Reconstituted Sodium Pump: A Historical Account

Anner, Beatrice Maier

Paperback

Chemistry

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ISBN10: 3389016015
ISBN13: 9783389016015
Publisher: Grin Verlag
Published: Apr 20 2024
Pages: 62
Weight: 0.20
Height: 0.15 Width: 5.83 Depth: 8.27
Language: English
Document from the year 2024 in the subject Chemistry - Bio-chemistry, language: English, abstract: The sodium pump, also called Na, K-ATPase (NKA) is a biomotor inserted in the membrane of all living cells; it extrudes sodium ions from the cell interior and replaces them with potassium ions. This is a fundamental and vital process. Furthermore, the sodium pump is also a receptor for pharmacological and toxicological compounds, such as the heart drug digitoxin and the arrow poison ouabain. Around 1974 it became possible to extract the sodium pump from the cell membrane and insert it into artificial phospholipid vesicles where it worked in the same way as in the cell. Now, the pump could be studied in its pure form on a molecular level. The author has been involved in this pioneering research and tells some fascinating stories concerning the first ultrastructural description of the reconstituted sodium pump in collaboration with specialists at Arhus University in Denmark and at Duke University in the US, and about the use of the reconstituted sodium pump for testing an unknown inhibitory compound in collaboration with Harvard Medical School.

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