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Proteostasis and Disease: From Basic Mechanisms to Clinics

Proteostasis and Disease: From Basic Mechanisms to Clinics

Hardcover

Series: Advances in Experimental Medicine and Biology, Book 1233

Medical ReferenceBiologyChemistry

ISBN10: 3030382656
ISBN13: 9783030382650
Publisher: Springer Nature
Published: Apr 10 2020
Pages: 348
Weight: 1.86
Height: 0.81 Width: 7.00 Depth: 10.00
Language: English

This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology.

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