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Proprotein Convertases
Hardcover
Series: Methods in Molecular Biology, Book 768
ISBN13: 9781617792038
Publisher: Springer Nature
Published: Aug 2 2011
Pages: 367
Weight: 1.80
Height: 1.00 Width: 7.10 Depth: 10.20
Language: English
Part I: Reminiscences
1. On the Discovery of Precursor Processing
Donald F. Steiner
2. The Prohormone Theory and the Proprotein Convertases: It Is All About Serendipity
Michel Chrétien
Part II: Biochemistry and Cell Biology
3. The Proprotein Convertases, 20 Years Later
Nabil G. Seidah
4. Insights from Bacterial Subtilases into the Mechanisms of Intramolecular Chaperone-Mediated Activation of Furin
Ujwal Shinde and Gary Thomas
5. The Novel Role of Cathepsin L for Neuropeptide Production Illustrated by Research Strategies in Chemical Biology with Protease Gene Knockout and Expression
Lydiane Funkelstein and Vivian Hook
6. In Vitro Assay for Protease Activity of Proprotein Convertase Subtilisin Kexins (PCSKs): An Overall Review of Existing and New Methodologies
Ajoy Basak, Andrew Chen, Swapan Majumdar, and Heather Palmer Smith
7. Inhibitor Screening of Proprotein Convertases Using Positional Scanning Libraries
Iris Lindberg and Jon R. Appel
8. Analyses of PCSK9 Post-Translational Modifications Using Time-of-Flight Mass Spectrometry
Thilina Dewpura and Janice Mayne
Part III: Molecular Biology and Genetics
9. The Molecular Biology of Furin-Like Proprotein Convertases in Vascular Remodelling
Philipp Stawowy and Kai Kappert
10. Identification of the Myosin Heavy Polypeptide 9 as a Downstream Effector of the Proprotein Convertases in the Human Colon Carcinoma HT-29 Cells
Nathalie Scamuffa, Fabien Calvo, and Abdel-Majid Khatib
11. Regulation of 7B2 mRNA Translation: Dissecting the Role of Its 5'-Untranslated Region
Haidy Tadros, Gunther Schmidt, Francine Sirois, and Majambu Mbikay
12. Analysis of Epigenetic Alterations to Proprotein Convertase Genes in Disease
YangXin Fu and Mark W. Nachtigal
13. Genetic and Functional Characterization of PCSK1
Hélène Choquet, Pieter Stijnen, and John W.M. Creemers
Part IV: Experimental Models
14. Prohormone Processing in Zebrafish
Michael G. Morash, Kelly Soanes, and Younes Anini
15. Use of Zebrafish and Knockdown Technology to Define Proprotein Convertase Activity
Babykumari P. Chitramuthu and Hugh P.J. Bennett
16. Characterization of Impaired Processing of Neuropeptides in the Brains of Endoproteases Knockout Mice
Margery C. Beinfeld
17. Quantitative Peptidomics of Mice Lacking Peptide-Processing Enzymes
Jonathan Wardman and Lloyd D. Fricker
18. A Proteomic Protocol to Identify Physiological Substrates of Proprotein Convertases
Guiying Nie and Andrew N. Stephens
19. Neurophenotyping Genetically-Modified Mice for Social Behavior
Ramona M. Rodriguiz, Jennifer S. Colvin, and William C. Wetsel
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