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As hormonas gastrointestinais
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ISBN10: 6207305175
ISBN13: 9786207305179
Publisher: Edicoes Nosso Conhecimento
Published: Mar 25 2024
Pages: 60
Weight: 0.22
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Portuguese
ISBN13: 9786207305179
Publisher: Edicoes Nosso Conhecimento
Published: Mar 25 2024
Pages: 60
Weight: 0.22
Height: 0.14 Width: 6.00 Depth: 9.00
Language: Portuguese
O trato gastrointestinal é a maior glândula endócrina em termos de número de hormonas segregadas e de tamanho. O TGI segrega mais de 30 hormonas e um certo número de péptidos bioactivos. O tubo digestivo endócrino forma um sistema neuronocrino difuso constituÃdo por células enterocromafins ou argentafinas e ilhéus de células de Langerhans. O sistema endócrino intestinal segrega hormonas peptÃdicas que podem ser agrupadas em sete famÃlias com base na sua homologia estrutural e na sua função1) A famÃlia das secretinas inclui a secretina, o VIP, o glucagon e os GLP-1 e GLP-2, a somatostatina, o péptido histidina-isoleucina, o péptido ativador da adenilil ciclase hipofisária.2) A famÃlia da gastrina é constituÃda pela gastrina e pela colecistoquinina. 3) A famÃlia das dobras PP é constituÃda pelo polipéptido pancreático, pelo neuropeptÃdeo Y e pelo péptido YY. 4) A famÃlia da somatostatina inclui a somatostatina e a corticostatina. 5) A famÃlia das taquicininas inclui a substância P e as neuroquininas. 6) A famÃlia da insulina inclui a insulina, a relaxina e os factores de crescimento semelhantes à insulina 1 e 2. 7) A famÃlia EGF inclui o fator de crescimento epidérmico, a anfiregulina e o fator de crescimento transformador alfa.São abordados a genética, o mecanismo de ação, a fisiologia e as correlações clÃnicas.
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