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Badanie dzialania przeciwwrzodowego ekstraktu LIS-014 u szczurów
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ISBN10: 6630461304
ISBN13: 9786630461305
Publisher: Wydawnictwo Nasza Wiedza
Published: Sep 8 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Polish
ISBN13: 9786630461305
Publisher: Wydawnictwo Nasza Wiedza
Published: Sep 8 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: Polish
Celem niniejszego badania bylo zbadanie dzialania LIS-014 in vivo u szczurów. Jego dzialanie ochronne na blonę śluzową badano w kontekście dzialania indometacyny podawanej wielokrotnie doustnie w dawce 30 mg/kg dziennie. Ponadto zbadano jego dzialanie hamujące wydzielanie poprzez podwiązanie odźwiernika, a na koniec jego dzialanie zobojętniające kwas badano poprzez reakcję neutralizacji między LIS-014 a treścią żolądkową. LIS-014 chroni blonę śluzową żolądka przed dzialaniem indometacyny. Zmniejsza powierzchnię zmian wrzodowych w blonie śluzowej zwierząt leczonych ekstraktem w porównaniu z grupą kontrolną. Dzialanie hamujące wydzielanie LIS-014 przejawia się wzrostem pH soku żolądkowego. LIS-014 wykazuje również dzialanie przeciwwykwasowe; jest w stanie bezpośrednio obniżyc kwasowośc soku żolądkowego poprzez reakcję kwasowo-zasadową u zwierząt, którym podano ekstrakt w dawce 600 mg/kg, pH wynosi 3,31 0,13 w porównaniu z 3,17 0,27 dla mieszaniny soku żolądkowego z LIS-014 (P > 0,05). Dzialania te mogą wynikac z obecności flawonoidów, antocyjanów, garbników i alkaloidów.
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