• Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Organic synthesis of heterocyclic 1,4-benzoxazepines

Organic synthesis of heterocyclic 1,4-benzoxazepines

Paperback

Chemistry

ISBN10: 6209563295
ISBN13: 9786209563294
Publisher: Our Knowledge Publishing
Published: Jan 23 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: English
This study focuses on the reactivity of 2 -aminobenzylalcohol with respect to geminalized epoxides (dicyano and cyano-ester) behaving as bi-electrophiles. The method enables highly efficient synthesis of 1,4-benzoxazepin-3-ones in very high yield, thanks to simple epoxide opening followed by cyclization. All products are characterized in minute detail by NMR, mass spectrometry and Fourier Transform Infrared spectrometry (FT-IR). With cyano-esters (2), the method enables the production of novel 1,4-benzoxazepines via an efficient one-pot reaction, without catalyst. Simple to perform, selective and achievable under mild conditions, this method opens up new prospects in medicinal chemistry, with the aim of designing new bioactive compounds.

Also from

El Ghmari, Brahim

Also in

Chemistry