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New Applications of NMR in Drug Discovery and Development

New Applications of NMR in Drug Discovery and Development

Hardcover

Series: New Developments in NMR, Book 2

Gifts & Stationery GeneralChemistryGeneral Science

ISBN10: 1849734445
ISBN13: 9781849734448
Publisher: Royal Society of Chemistry
Published: Jul 24 2013
Pages: 565
Weight: 2.23
Height: 1.71 Width: 6.40 Depth: 9.35
Language: English

This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods in NMR, many of which are not widely applied but are likely to provide new opportunities for drug design.

The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and interaction with targets. Particular emphasis is put on applications with unexploited potential for drug discovery and development. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity.

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Chemistry