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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
An N Investigation of Microrna Target Regulation Mechanisms Using an Integrative Approach

An N Investigation of Microrna Target Regulation Mechanisms Using an Integrative Approach

Schmitz, Ulf

Paperback

BiologyGeneral Computers

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ISBN10: 3832540059
ISBN13: 9783832540050
Publisher: Logos Verlag Berlin
Published: Jun 29 2015
Pages: 192
Weight: 0.55
Height: 0.48 Width: 5.68 Depth: 8.04
Language: English
This work is a showcase for the integration of systems biology and bioinformatics tools, algorithms and models for deciphering biological phenomena. More specifically, it integrates (i) prediction algorithms for identifying and characterizing molecular interactions, (ii) structural modelling of molecule complexes, (iii) network analysis approaches, and (iv) mathematical modelling and simulation. Two comprehensive workflows are implemented for the analysis of collective target gene regulation by microRNAs and for the prediction of cooperating microRNA pairs and their mutual target genes. In two case studies mechanisms of fine-tuned target gene regulation are revealed for different cellular processes and the phenomenon of cooperative target regulation is identified as frequent mechanism of gene regulation in humans.

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