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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Monoclonal Antibodies to Receptors: Probes for Receptor Structure and Funtcion

Monoclonal Antibodies to Receptors: Probes for Receptor Structure and Funtcion

Greaves, M. F.

Hardcover

Medical ReferenceChemistryZoology

ISBN10: 0412253305
ISBN13: 9780412253300
Publisher: Springer
Published: Sep 30 1984
Pages: 324
Weight: 1.45
Height: 0.81 Width: 6.14 Depth: 9.21
Language: English
Receptor specific antibodies are excellent probes for a wide range of biological investigations on receptor structure and function. The hybridoma technology (Kohler and Milstein, 1975) has inevitably had a major impact on this field with most of the better known receptors now identified with monoclonal antibodies. This volume of the Receptors and Recognition series provides reviews of recent developments in this field and emphasizes in particular the new opportunities afforded by the judicious application of monoclonal reagents. It is assumed that most readers will be familiar with the now fairly routine methods of cell fusion, hybridoma cloning and selection for producing monoclonal antibodies and so few details of the basic technical procedures are described. Several good reviews on this topic are however available (see Galfre and Milstein, 1981; Goding, 1980; Yelton and Scharf, 1981; McMichael and Fabre, 1982). By no means all vertebrate receptor species are discussed here; omissions include antibodies to low density lipoprotein receptors (Beisiegel et al., 1981; Kita et al., 1981), prolactin and growth hormone receptors (Friesen etal., 1982; Simpson et al., 1983) and the hepatocyte asialoglycoprotein receptor (Schwartz et al., 1981; Harford et al., 1982). Nevertheless the coverage is comprehensive and critical and the individual chapters provided illustrate vividly the rapid progress being made.

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