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    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

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Molecular Mechanisms for Repair of DNA: Part B

Molecular Mechanisms for Repair of DNA: Part B

Hanawalt, Philip

Paperback

Series: Basic Life Sciences, Book 5

BiologyZoology

ISBN10: 1468429000
ISBN13: 9781468429008
Publisher: Springer Nature
Published: Nov 17 2012
Pages: 425
Weight: 1.36
Height: 0.90 Width: 6.14 Depth: 9.21
Language: English
The excision-repair of ultraviolet-induced lesions in DNA involves a recogni- tion and incision step which is followed by excision of the damaged material, DNA repair resynthesis, and sealing of the fmal gap by polynucleotide ligase (e.g. Howard-Flanders, 1968). The initial incision step appears to require an endo- nuclease which is absent in the uvrA and uvrR mutants of E. eoli K12 (Braun et al., Part A of this book). The polAl strains are deficient in DNA polymerase I activity (de Lucia and Cairns, 1969) and are partially deficient in repairing single-strand breaks in DNA (incision breaks) produced by the excision-repair process (Kanner and Hanawalt, 1970; Paterson et al., 1971). Most of the repair of incision breaks which occurs in the polAl strain appears to require DNA polymerase III (Youngs and Smith, 1973b). Thus, both DNA polymerases I and III have been implicated in the DNA repair resynthesis step of the excision-repair process. Masker et al. (1973) have shown that DNA polymer ase 11 (deficient in polB mutants, Campbell et al., 1972) is involved in UV-induced repair replication in toluene-treated cells which lack both DNA polymerase I and normal DNA replication. However, DNA polymerase 11 is probably not involved in a major way in repair processes in vivo, since wild-type or polAl cells which also contain a polR mutation are no more sensitive to UV or X-radiation than the related polB+ strains (Campbell et al., 1972; Youngs and Smith, 1973e).

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