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Laboratory Guide in Experimental Pharmacology

Laboratory Guide in Experimental Pharmacology

Paperback

General World History

ISBN10: 0217009484
ISBN13: 9780217009485
Publisher: General Books
Published: Jan 15 2012
Pages: 40
Weight: 0.20
Height: 0.08 Width: 7.44 Depth: 9.69
Language: English
Purchase of this book includes free trial access to www.million-books.com where you can read more than a million books for free. This is an OCR edition with typos. Excerpt from book: Chemistry of Drugs. Alkaloids. Among the most important of the organic compounds employed in medicine is the group of vegetable bases known as Alkaloids. They are found in almost all parts of plants, but in greatest abundance in the seeds and roots. They constitute in almost all cases the active constituents of the plants in which they are found and some of them are among the most powerful poisons known. The alkaloids contain carbon, hydrogen, nitrogen, and usually oxygen, but in a few instances the latter is not present. In their chemical properties they resemble ammonia very closely, having an alkaline reaction and uniting with acids without the elimination of hydrogen to form salts. These salts differ from the alkaloids in their solubility, and upon this fact is based one method of isolating them in a pure form from the plants in which they are found. One of the most familiar alkaloids is quinine, which is derived from various species of cinchona bark, and it may be taken as a type of the group, as the reactions given by it are characteristic of most of the other alkaloids. Taste quinine and quinine sulphate. I. Test the solubility of a few crystals of quinine (alkaloid) and of quinine sulphate (alkaloidal salt) in 10 cc. of each of the following: Solvent.Alkaloid solubility.Alkaloidal salt solubility.aWater. bAlcohol. 0Ether. dChloroform. II. Add about 100 cc. of water to 0.2 G. quinine. Shake the flask and observe only a small part goes into solution. Test the reaction of the solution with litmus. How do you explain the reaction? Add 1 cc. dilute sulphuric acid and shake until complete solution takes place. The sulphuric acid formed the bisul- phate of the alkaloid. (Note the fluorescence of the solution which is characteristic of quinine.) Use...

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