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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Ion Transport Through Biological Membranes: An Integrated Theoretical Approach

Ion Transport Through Biological Membranes: An Integrated Theoretical Approach

Mackey, M. C.
Mackey, Michael C.

Hardcover

Series: Lecture Notes in Biomathematics, Book 7

BiologyGeneral Mathematics

Currently unavailable to order

ISBN10: 0387075321
ISBN13: 9780387075327
Publisher: Springer Nature
Published: Jan 1 1976
Pages: 240
Language: English
This book illustrates some of the ways physics and mathematics have been, and are being, used to elucidate the underlying mechan- isms of passive ion movement through biological membranes in general, and the membranes of excltable cells in particular. I have made no effort to be comprehensive in my introduction of biological material and the reader interested in a brief account of single cell electro- physlology from a physically-oriented biologists viewpoint will find the chapters by Woodbury (1965) an excellent introduction. Part I is introductory in nature, exploring the basic electrical properties of inexcitable and excitable cell plasma membranes. Cable theory is utilized to illustrate the function of the non-decrementing action potential as a signaling mechanism for the long range trans- mission of information in the nervous system, and to gain some in- sight into the gross behaviour of neurons. The detailed analysis of Hodgkin and Huxley on the squid giant axon membrane ionic conductance properties is reviewed briefly, and some facets of membrane behaviour that have been revealed since the appearance of their work are dis- cussed. Part II examines the foundations of electrodiffusion theory, and the use of that theory in trying to develop quantitative expla- nationsof the observed membrane properties of excitable cells, in particular the squid giant axon. In addition, an ad hoc formulation of electrodiffusion theory including active transport is presented to illustrate the qualitative nature of cellular homeostasis with respect to intracellular ionic concentrations and membrane potential, and cellular responses to prolonged stimUlation.

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