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Heteroaromatic Lipoxin A4 Analogues: Synthesis and Biological Evaluation
Paperback
Series: Springer Theses
ISBN13: 9783642438929
Publisher: Springer Nature
Published: Feb 22 2014
Pages: 130
Weight: 0.48
Height: 0.50 Width: 6.00 Depth: 9.00
Language: English
In this thesis Colm Duffy reviews the chemistry and biology of stable lipoxin analogues. Colm has prepared for the first time ever a pyridine-containing LXA4 analogue in enantiomerically pure form. Biological evaluation determined that both epimers at the benzylic position suppress key cytokines known to be involved in inflammatory disease, with the (R)-epimer proving most efficacious. Moreover the author developed an excellent route to a related thiophene-containing analogue that also showed interesting biological activity. Both routes have inspired further work in the synthesis of further heteroaromatic analogues for biological evaluation.
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