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Hepatic Transport of Organic Substances

Hepatic Transport of Organic Substances

Paperback

Series: Proceedings in Life Sciences

Medical ReferenceChemistry

ISBN10: 3642742491
ISBN13: 9783642742491
Publisher: Springer Nature
Published: Jan 5 2012
Pages: 435
Weight: 1.59
Height: 0.92 Width: 6.69 Depth: 9.61
Language: English
Hepatic cells are involved in the metabolization and elimination of a variety of endogenous and exogenous substances. They mediate the uptake, processing and subsequent secretion of biliary compounds, such as various drugs or hormones, and the passage of metabolites to be released into different blood compartments. To perform vectorial passages hepatocytes show a strong polarity with sites for endocytotic processes or specific carrier molecules, and a specified system of organelles for intracellular transport and sorting, metabolization and secretion of compounds. Several aspects, e.g. regulation, control and mechanisms of hepatic traffic are reported in detail - complemented by methodological approaches to analyse and monitor these processes.

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Chemistry