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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Gamma-Glutamyl Transpeptidases: Structure and Function

Gamma-Glutamyl Transpeptidases: Structure and Function

Castellano, Immacolata
Merlino, Antonello

Paperback

Series: Springerbriefs in Biochemistry and Molecular Biology

Medical ReferenceTechnology & EngineeringChemistry

ISBN10: 3034806817
ISBN13: 9783034806817
Publisher: Springer Nature
Published: Jul 25 2013
Pages: 57
Weight: 0.25
Height: 0.30 Width: 5.90 Depth: 8.90
Language: English
Gamma-Glutamyl Transpeptidases (γ-GTs) are members of the N-terminal nucleophile hydrolase superfamily, enzymes that cleave the γ-glutamyl amide bond of glutathione to liberate cysteinylglycine. The released γ-glutamyl group can be transferred to water (hydrolysis) or to amino acids or short peptides (transpeptidation). γ-GT plays a key role in the gamma glutamyl cycle by regulating the cellular levels of the antioxidant glutathione, hence it is a critical enzyme in maintaining cellular redox homeostasis.γ-GT is upregulated during inflammation and in several human tumors, and it is involved in many physiological disorders related to oxidative stress, such as Parkinson's disease and diabetes. Furthermore, this enzyme is used as a marker of liver disease and cancer. This book covers current knowledge about the structure-function relationship of γ-GTs and gives information about applications of γ-GTs in different fields ranging from clinical biochemistry to biotechnology and biomedicine.​

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