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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Gold(i, III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Gold(i, III) Complexes Designed for Selective Targeting and Inhibition of Zinc Finger Proteins

Ferraz de Paiva, Raphael Enoque

Paperback

Series: Springer Theses

ChemistryGeneral Science

ISBN10: 3030131505
ISBN13: 9783030131500
Publisher: Springer Nature
Published: Dec 10 2019
Pages: 151
Weight: 0.61
Height: 0.41 Width: 6.14 Depth: 9.21
Language: English

This book examines Au (I, III) complexes that selectively attack and inhibit zinc finger proteins (ZnFs) for potential therapeutic use. The author explores gold(I)-phosphine, gold(III) complexes with N N and C N donors as inhibitors of the HIV-1 nucleocapsid protein (NCp7), in comparison to the human transcription factor Sp1. To determine the coordination sphere of the gold adducts formed by interaction with ZnFs, two innovative approaches are used, based on Travelling-Wave Ion Mobility coupled with Mass Spectrometry (TWIM-MS), and X-ray Absorption Spectroscopy. Both approaches are proven to yield valuable structural information regarding the coordination sphere of gold in the adducts. In addition, the organometallic compound [Au (bnpy)Cl2] is evaluated. The system is shown to be capable of inhibiting ZnFs by means of C-S coupling.

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