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Multiskalenmodellierung Der Progression Von Glioblastomen: Ein Ansatz Unter Der Berücksichtigung Molekularer Und Zellulärer Prozesse
Paperback
Series: Aktuelle Forschung Medizintechnik - Latest Research in Medic
Technology & EngineeringGeneral ComputersGeneral Mathematics
ISBN13: 9783658070748
Publisher: Springer Nature
Published: Oct 23 2014
Pages: 194
Weight: 0.62
Height: 0.48 Width: 5.83 Depth: 8.27
Language: German
Tina Anne Schütz entwickelt und diskutiert ein neues Multiskalenmodell zur Abbildung der frühen Wachstumsphase von Glioblastomen. Um mehrere Skalen abzubilden, koppelt die Autorin ein hybrides Modell auf der mikroskopischen Ebene mit dem Modell eines molekularen Interaktionsnetzwerkes. Durch den Vergleich mit In-vitro-Daten validiert sie das Modell und führt Simulationen durch, um so Rückschlüsse für die Biologie und Medizin zu ziehen. Insbesondere liefert das Modell Hinweise auf neue prognostische Marker für die Progression von Glioblastomen und auf neue Therapieansätze.
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