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Modellierung Zellulärer Gliomwachstumsprozesse in Ihrer Mikroumgebung
Paperback
Series: Aktuelle Forschung Medizintechnik - Latest Research in Medic
ISBN13: 9783658046835
Publisher: Springer Vieweg
Published: Dec 27 2013
Pages: 161
Weight: 0.49
Height: 0.38 Width: 5.83 Depth: 8.27
Language: German
Krebs ist eines der weitverbreitetsten Krankheitsbilder im Erwachsenenalter und steht zunehmend im Zentrum unterschiedlicher wissenschaftlicher Disziplinen. Alina Toma befasst sich mit der mathematischen Modellierung der Progression des Glioblastoms. Für eine realitätsnahe Simulation des zellulären Wachstums des Tumors berücksichtigt sie Umgebungsfaktoren wie Nährstoffe und die extrazelluläre Matrix. Sie betrachtet neben Migration und Proliferation von Tumorzellen weitere Zellstatus wie Zelltod oder Ruhezustand. Die Autorin integriert zum ersten Mal die Immunzellen des zentralen Nervensystems in ein Glioblastom-Wachstumsmodell, wobei sie relevante in-vitro Experimente zur Validierung des Modells hinzufügt. Die Arbeit führt in die Strahlentherapie und Multiskalenmodellierung ein und greift die wichtigen Aspekte der Tumormikroumgebung auf, um so eine realistische Darstellung der Wachstumsprozesse abzubilden.
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