Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
612-822-4611

  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Flavonoids of Pepper as Cytokines Inhibitors

Flavonoids of Pepper as Cytokines Inhibitors

Allam, Ahmed Ezzaldean Abdellah

Paperback

General Science

ISBN10: 1636481825
ISBN13: 9781636481821
Publisher: Eliva Pr
Published: Apr 30 2021
Pages: 42
Weight: 0.15
Height: 0.09 Width: 6.00 Depth: 9.00
Language: English
Various naturally occurring phytochemicals exhibit anti-inflammatory activity and are considered to be potential drug candidates against inflammation-related pathological processes. Here, new flavonoid glycoside, kaempferol 3-O-α-¬[(6-P coumaroyl galactopyranosyl-O-β- (1→4)-O-α-rhamnopyranosyl-(1→4)]-O-α-rhamnopyranoside 1, in addition to five known flavonoid glycosides (2-6) kaempferol 3-O-[α- ¬rhamnopyranosyl-(1→4)-O-α-rhamnopyranosyl-(1→6)-O]-β- galactopyranoside (kaempferol 3-O-β-isorhamninoside) 2, quercetin 3-O- [(2,3,4-triacetyl-α-rhamnopyranosyl)-(1→6)-β-galactopyranoside 3, quercetin 3-O-[(2,4-diacetyl-α-rhamnopyranosyl)-(1→6)]-3,4-diacetyl-β- galactopyranoside 4, quercetin 3-O-[(2,4-diacetyl-α-rhamnopyranosyl)- (1→6)]-2,4-diacetyl-β-galactopyranoside 5, quercetin 3-O-[(2,3,4-triacetyl- α-rhamnopyranosyl)-(1→6)-3-acetyl-β-galactopyranoside 6 were isolated from bell pepper (Capsicum annum L.) fruits and tested for both antiinflammatory activity through cytokine production (TNF-α and IL-1β) and antioxidant activity through scavenging effect on 1,1-diphenyl-2- picrylhydrazyl (DPPH) assay. Compounds 1-3 significantly suppressed production of TNF-α / IL-1β in cultured THP-1 cells previously costimulated by LPS in a dose-dependent manner (10.2/49.1, 28.1/55.7, and 35.2/57.5 μM respectively) whereas compounds 4-6 have relatively weaker inhibitory activity. (45.3/73.5, 48.2/65.6, and 42.2/67.4 μM respectively). All compounds 1-6 showed no cytotoxic activity against the growth of THP-1where the percentage of cell viability was (127.4, 108.5, 105.4, 103.9, 103.4, and 104.2 μM respectively). All isolated compounds exhibited higher radical scavenging activity than ascorbic acid in (DPPH) assay. These results indicated that bell pepper fruits could be an effective candidate for ameliorating inflammatory-associated complications.

Also in

General Science

View All