Sign-In
Cart
Fibrinogen Memoirs: Journeys of a Clot Doctor
Paperback
Biographies GeneralMedical Reference
Publisher Price: $35.00
ISBN13: 9781949093650
Publisher: Ipbooks
Published: Aug 9 2020
Pages: 260
Weight: 1.34
Height: 0.55 Width: 8.50 Depth: 11.00
Language: English
Following graduation from SUNY-Downstate Medical School in Brooklyn, New York, Michael Mosesson had intended to pursue a Surgical career under the aegis of his former Professor, Clarence Dennis. But life took a different turn. He wound up instead in The United States Public Health Service, stationed at the Division of Biologics Standards on The National Institutes of Health (NIH) campus. During his experiences with research and governmental regulatory control, he began to investigate the circulating precursor of a Fibrin Clot, Fibrinogen. Fibrinogen plays a critical role in many physiological and disease conditions, such as blood clotting, wound healing, hemophilic conditions, thrombotic conditions such as deep vein thrombosis, pulmonary embolism, stroke, heart attacks, and microvascular thromboses (all of which have occurred in COVID-19 patients).
Mosesson's surgical plans never materialized, and he turned instead to Fibrinogen, a subject that would involve him as a Scientist and Clinician for the next fifty-two years. In this book, he writes about his investigative, organizational, and societal experiences:
- Production of Transgenic Human Fibrinogen in cows' milk.
- Discovery of the plasma form of a ubiquitous tissue protein known as Fibronectin.
- Identification and isolation of circulating partially degraded forms of Fibrinogen, Fibrinogen Catabolites.
- Investigations of Structural and Functional Properties of an Assembled Fibrin Clot, as well as the long-lasting controversy they engendered.
- A 50 year-long search to identify a potent inhibitor of clot lysis (Fibrinolysis) found in fibrinogen preparations that is now known as α2-Antiplasmin.
- Studies of Dysfibrinogenemias, congenital fibrinogen abnormalities.
- Developing a Transgenic Humanized Mouse Fibrinogen model to study the function of the blood clotting inhibitor known as Antithrombin I.
- Founding the International Fibrinogen Research Society.
Mosesson includes a chapter describing events that accompanied his career as a Pilot, covering a period extending from his days at NIH until his retirement fifty years later. There is also a section written by his friend and colleague, John S. Finlayson, who described the transition of The Division of Biologics Standards to a subsidiary of The Food and Drug Administration (FDA). Finally, he provides an Annotated Bibliography with commentaries and personal insights into many of his published works. The presentations of scientific subject matter are accurate although technical details are minimized for clarity. Narratives are developed around personal interactions and involvements with colleagues, associates, friends, and adversaries, highlighted by many humorous events and anecdotes.
Also from
Mosesson, Michael W.
Fibrinogen Memoirs 2: The Rise and Fall of the Fibrin Cross-linking Controversy
Mosesson, Michael W.
Paperback
Also in
Biographies General
Bluesland: Portraits of Thirteen Major American Blues Masters
Toby Byron (ED.)
Pete Welding (ED.)
Hardcover
Karl Popper - The Formative Years, 1902 1945: Politics and Philosophy in Interwar Vienna
Hacohen, Malachi Haim
Hardcover
The Children of Athena: Greek Intellectuals in the Age of Rome: 150 Bc0-400 AD
Freeman, Charles
Hardcover
Make It a Double: From Wretched to Wondrous: Tales of One Woman's Lifelong Discovery of Whisky
Sackier, Shelley
Hardcover
The Code Breaker: Jennifer Doudna, Gene Editing, and the Future of the Human Race
Isaacson, Walter
Hardcover
An Enemy Such as This: Larry Casuse and the Fight for Native Liberation in One Family on Two Continents Over Three Centuries
Correia, David
Hardcover
Agents of Chaos: Thomas King Forçade, High Times, and the Paranoid End of the 1970s
Howe, Sean
Hardcover
Better Living Through Birding: Notes from a Black Man in the Natural World
Cooper, Christian
Hardcover
The Secret Life of the Savoy: Glamour and Intrigue at the World's Most Famous Hotel
Williams, Olivia
Paperback
The Badger: The Life of Bernard Hinault and the Legacy of French Cycling
Fotheringham, William
Paperback
The Devil's Diary: Alfred Rosenberg and the Stolen Secrets of the Third Reich
Wittman, Robert K.
Kinney, David
Paperback
Florence Kelley and the Nation's Work: The Rise of Womens Political Culture, 1830-1900
Sklar, Kathryn Kish
Paperback
A Woman of No Importance: The Untold Story of the American Spy Who Helped Win World War II
Purnell, Sonia
Hardcover
Living with a Wild God: A Nonbeliever's Search for the Truth about Everything
Ehrenreich, Barbara
Paperback
Seafaring Women: Adventures of Pirate Queens, Female Stowaways, and Sailors' Wives
Cordingly, David
Paperback
The Butcher, the Embezzler, and the Fall Guy: A Family Memoir of Scandal and Greed in the Meat Industry
Cherington, Gretchen
Paperback
Gift of Power: The Life and Teachings of a Lakota Medicine Man
Lame Deer, Chief Archie Fire
Erdoes, Richard
Paperback
My Own Devices: True Stories from the Road on Music, Science, and Senseless Love
Dessa Wander
Hardcover
Nobody's Girl: A Memoir of Surviving Abuse and Fighting for Justice
Giuffre, Virginia Roberts
Hardcover
How to Be Okay When Nothing Is Okay: Tips and Tricks That Kept Me Alive, Happy, and Creative in Spite of Myself
Lawson, Jenny
Hardcover
Family of Spies: A World War II Story of Nazi Espionage, Betrayal, and the Secret History Behind Pearl Harbor
Kuehn, Christine
Hardcover
Dangerous, Dirty, Violent, and Young: A Fugitive Family in the Revolutionary Underground
Dohrn, Zayd Ayers
Hardcover
Catch the Devil: A True Story of Murder, Deception, and Injustice on the Gulf Coast
Colloff, Pamela
Hardcover
A Walk in the Park: The True Story of a Spectacular Misadventure in the Grand Canyon
Fedarko, Kevin
Paperback