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Evolutionary Systems Biology
Hardcover
Series: Advances in Experimental Medicine and Biology, Book 751
Medical ReferenceEvolutionGeneral Science
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ISBN10: 1461435668
ISBN13: 9781461435662
Publisher: Springer
Published: Jul 21 2012
Pages: 458
Weight: 1.90
Height: 1.20 Width: 6.30 Depth: 9.20
Language: English
ISBN13: 9781461435662
Publisher: Springer
Published: Jul 21 2012
Pages: 458
Weight: 1.90
Height: 1.20 Width: 6.30 Depth: 9.20
Language: English
Preface.- Evolutionary Systems Biology: Historical and Philosophical Persepctives on an Emerging Synthesis.- Metabolic Networks and their Evolution.- Organization Principles and their Evolution.- Organization principles in genetic interaction networks.- Evolution of regulatory networks: Nematode vulva induction as an example of developmental systems drift.- Life's attractors understanding developmental systems through reverse engineering and in silico evolution.- Evolutionary characteristics of bacterial two-component systems.- Comparative interaction networks - bridging genotype to phenotype.- Evolution in silico: from network structure to bifurcation theory.- On the search for design principles in biological systems.- Towards a theory of multilevel evolution; long term information integration shapes the mutational landscape and enhances evolvability.- Evolutionary principles underlying structure and response dynamics of cellular networks.- Phenotypic plasticity and robustness: Evolutionary stability theory, gene expression dynamics model, and laboratory experiments.- Genetic redundancies and their evolutionary maintenance.- Evolution of resource and energy management in biologically realistic gene regulatory network models.- Reverse ecology: From systems to environments and back.- Bacteria-virus coevolution.- The genotype-phenotype maps of systems biology and quantitative genetics: distinct and complementary.- How evolutionary systems biology will help understand adaptive landscapes and distributions of mutational effects.- Building synthetic systems to learn Nature's design principles.- The robustness continuum.- Index.
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