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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Evaluation of the genotoxicity of plant extracts.

Evaluation of the genotoxicity of plant extracts.

Martell Enríquez, Roxana
Sánchez Hechavarría, Laura
Sánchez Lamar, Ángel

Paperback

General Science

ISBN10: 6209619576
ISBN13: 9786209619571
Publisher: Our Knowledge Publishing
Published: Feb 27 2026
Pages: 52
Weight: 0.18
Height: 0.12 Width: 6.00 Depth: 9.00
Language: English
This study investigated the genetic safety of hydroalcoholic extracts of Calendula officinalis, Cecropia peltata and Petiveria alliacea, plants with therapeutic potential in Cuba for their antioxidant and anti-inflammatory properties. The objective was to evaluate their genotoxicity to rule out risks of mutations or degenerative diseases before their pharmacological application. Using an ex vivo plasmid DNA biomodel, the clastogenicity was evaluated at concentrations of 1 - 1000 μg/ml. Results at 30 min exposure indicated that none of the species caused damage to the genetic material. By extending the incubation time up to 4 h at the maximum dose, C. officinalis and C. peltata maintained their safety, ratifying them as safe candidates for future bioactivity studies. In contrast, P. alliacea extract showed chain breaks in treatments >= 2 hours at 1000 μg/ml, suggesting the need for future genotoxicity testing with experimental biomodels of higher complication.

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