Open Daily: 10am - 10pm | Alley door pickup 10am - 7pm 3038 Hennepin Ave Minneapolis, MN
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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Engineering of Halogenases Towards Synthetic Applications: Increasing the Thermostability and Investigations on a Marine Brominase Bmp5

Engineering of Halogenases Towards Synthetic Applications: Increasing the Thermostability and Investigations on a Marine Brominase Bmp5

Minges, Hannah

Paperback

Series: Bestmasters

Chemistry

ISBN10: 3658184094
ISBN13: 9783658184094
Publisher: Springer Spektrum
Published: May 23 2017
Pages: 116
Weight: 0.36
Height: 0.28 Width: 5.83 Depth: 8.27
Language: English
Hannah Minges focuses on the investigation of two different FAD-dependent halogenases in order to analyze and improve their applicability for chemoenzymatic approaches in chemistry. Owing to beneficial features, like high selectivity and benign reaction conditions, nature's toolkit for halogenation provides several advantages, whereas conventional chemical strategies require hazardous reagents and suffer from low selectivity. Therefore, enzymatic halogenation arises as promising alternative in the synthesis of valuable chemicals. One project focuses on the generation of a thermostable variant of the tryptophan halogenase Thal by means of directed evolution. The second project deals with the investigation of the marine halogenase Bmp5. This enzyme is of synthetic interest because it preferably introduces bromine into phenol compounds, whereas chlorination cannot take place.

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