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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Differential Display Methods and Protocols

Differential Display Methods and Protocols

Liang, Peng
Meade, Jonathan
Pardee, Arthur B.

Hardcover

Series: Methods in Molecular Biology, Book 317

BiologyChemistry

ISBN10: 1588293386
ISBN13: 9781588293381
Publisher: Springer Nature
Published: Oct 21 2005
Pages: 320
Weight: 2.66
Height: 1.08 Width: 6.34 Depth: 9.34
Language: English
Since the first edition of this book dedicated to differential display (DD) technology was published in 1997, we have witnessed an explosive interest in studying differential gene expression. The gene-hunting euphoria was initially powered by the invention of DD, which was gradually overtaken by DNA microarray technology in recent years. Then why is there still the need for second edition of this DD book? First of all, DD still enjoys a substantial lead over DNA microarrays in the ISI citation data (see Table 1), despite the h- dreds of millions of dollars spent each year on arrays. This may come as a surprise to many, but to us it implies that many of the DNA microarray studies went unpublished owing to their unfulfilled promises (1). Second, unlike DNA microarrays, DD is an open-ended gene discovery method that does not depend on prior genome sequence information of the organism being studied. As such, DD is applicable to the study of all living organisms--from bacteria, fungi, insects, fish, plants, to mammals--even when their genomes are not sequenced. Second, DD is more accessible technically and financially to most cost-conscious cottage-industry academic laboratories. So clearly DD still has its unique place in the modern molecular biological toolbox for gene expression analysis.

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