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Comparative Gene Finding: Models, Algorithms and Implementation

Comparative Gene Finding: Models, Algorithms and Implementation

Hardcover

Series: Computational Biology, Book 20

Anatomy & PhysiologyBiologyGeneral Computers

ISBN10: 1447166922
ISBN13: 9781447166924
Publisher: Springer
Published: Apr 22 2015
Pages: 382
Weight: 1.63
Height: 0.94 Width: 6.14 Depth: 9.21
Language: English
This book presents a guide to building computational gene finders, and describes the state of the art in computational gene finding methods, with a focus on comparative approaches. Fully updated and expanded, this new edition examines next-generation sequencing (NGS) technology. The book also discusses conditional random fields, enhancing the broad coverage of topics spanning probability theory, statistics, information theory, optimization theory and numerical analysis. Features: introduces the fundamental terms and concepts in the field; discusses algorithms for single-species gene finding, and approaches to pairwise and multiple sequence alignments, then describes how the strengths in both areas can be combined to improve the accuracy of gene finding; explores the gene features most commonly captured by a computational gene model, and explains the basics of parameter training; illustrates how to implement a comparative gene finder; examines NGS techniques and how to build a genome annotation pipeline.

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