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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
The Characterization of a Novel and Essential Trypanosome Protein.

The Characterization of a Novel and Essential Trypanosome Protein.

Whitecavage, Kellie Ann

Paperback

Chemistry

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ISBN10: 1243015152
ISBN13: 9781243015150
Publisher: Proquest Umi Dissertation Pub
Pages: 76
Weight: 0.37
Height: 0.20 Width: 7.99 Depth: 10.00
Language: English
African sleeping sickness, which is caused by the eukaryotic protozoan Trypanosoma brucei, is an epidemic in many African communities. RNA Polymerase II-dependent gene transcription in trypanosomes is unusual in many regards. Polycistronic transcripts are generated. There are very few introns. A 39-nucleotide capped spliced leader (SL) RNA is trans-spliced onto the 5' end of messages. The SL RNA gene is transcribed by RNA Polymerase II, and contains the only identified RNA Polymerase II promoter element to date. Recent studies found that the general transcription factor TbTFIIB is essential for SL RNA gene transcription. A study of Tb TFIIB associating factors revealed a unique protein (TAF49, TFIIB associating factor, 49 kDA). This protein bears many hallmarks associated with transcription factors. The work herein demonstrates a tight interaction between TbTFIIB and TbTAF49, suggesting a role for TbTAF49 in RNA polymerase II-dependent gene transcription. Furthermore, the TbTAF49 protein is essential for trypanosome viability, as determined by RNA interference studies.

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