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  • Open Daily: 10am - 10pm
    Alley-side Pickup: 10am - 7pm

    3038 Hennepin Ave Minneapolis, MN
    612-822-4611

Open Daily: 10am - 10pm | Alley-side Pickup: 10am - 7pm
3038 Hennepin Ave Minneapolis, MN
612-822-4611
Cardiac Rate and Rhythm: Physiological, Morphological and Developmental Aspects

Cardiac Rate and Rhythm: Physiological, Morphological and Developmental Aspects

Bouman, L. N.
Jongsma, H.

Paperback

Series: Developments in Cardiovascular Medicine, Book 17

Medical ReferenceOther Animals

ISBN10: 9400975376
ISBN13: 9789400975378
Publisher: Springer Nature
Published: Oct 12 2011
Pages: 696
Weight: 2.12
Height: 1.40 Width: 6.14 Depth: 9.21
Language: English
In the denervated state the mammalian heart, both in vivo and in vitro, is excited at very regular intervals, the coefficient of variance of the interbeat intervals not exceeding 2%. The pacemaker that is the source of this regular ex- citation is localised normally within the sinus node ( sino-atrial node node of Keith and Flack), a most intriguing small piece of tissue in the caval corner of the right atrium. A small portion of this node containing a group of probably only a few thousands of cells fires spontaneously, that means without any exter- nal influence to trigger their activity. The so called pacemaker cells do this by letting their membrane potential fall to the level where an action potential will start which subsequently activates surrounding cells to fire an action po- tential. The first question which is tackled in this book is which processes underly this spontaneous diastolic depolarization. This is discussed in section I, concerning the fundamental properties of pacemaker cells with special refer- ence to ionic membrane currents. Although views still quite differ about the exact nature of the membrane processes that cause the automatic pacemaker dis- charge there is agreement that diastolic depolarization is brought about by the interaction of a number of ionic current systems, including both inward and out- ward going currents.

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